|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
adefovir (ADV);lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
21816062
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2011 |
|
Journal
|
Virology journal |
|
Title
|
Lamivudine plus adefovir is a good option for chronic hepatitis B patients with viral relapse after cessation of lamivudine treatment. |
|
Author
|
Wang Z,Wu XL,Zeng WZ,Xu H,Zhang Y,Qin JP,Jiang MD |
|
Evidence
|
During 1-year retreatment, five patients receiving LAM alone had virological breakthrough and all of them had LAM resistance strains (rtM204V/I), while no LAM- or ADV- associated resistance strains were detected in patients receiving LAM plus ADV.
|
|
|
HBV Mutation Detail Information