|
Mutation Information
|
Mutation Site
|
A194T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
tenofovir (TDF) |
Literature Information
|
PubMed PMID
|
19028525
|
|
Published Year
|
2009 |
|
Journal
|
Antiviral research |
|
Title
|
Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir. |
|
Author
|
Seifer M,Patty A,Serra I,Li B,Standring DN |
|
Evidence
|
Conversely, against HBV cell line expressing adefovir resistance mutations N236T and A181V, or the A194T mutant associated with resistance to tenofovir, telbivudine remained active as shown by respective fold-changes of 0.
|
|
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HBV Mutation Detail Information