|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
21503906
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2011 |
|
Journal
|
Journal of medical virology |
|
Title
|
Clinical course and predictive factors of virological response in long-term lamivudine plus adefovir dipivoxil combination therapy for lamivudine-resistant chronic hepatitis B patients. |
|
Author
|
Aizawa M,Tsubota A,Fujise K,Tatsuzawa K,Kono M,Hoshina S,Tajiri H |
|
Evidence
|
Amino acid substitutions associated with both LAM resistance (rtL80, rtV173, rtL180, rtM204) and ADV resistance (rtA181, rtI233, rtN236) were detected in case 1 (rtL180M + rtA181A/V).
|
|
|
HBV Mutation Detail Information