Mutation Information
Mutation Site
|
T184S |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.T184S+rt.M204V |
Genotype/Subtype
|
D |
Country
|
Italy+other countries |
Literature Information
PubMed PMID
|
19041149
|
Disease
|
HBV infection
|
Published Year
|
2009 |
Journal
|
Journal of hepatology |
Title
|
The profile of mutational clusters associated with lamivudine resistance can be constrained by HBV genotypes. |
Author
|
Svicher V,Gori C,Trignetti M,Visca M,Micheli V,Bernassola M,Salpini R,Gubertini G,Longo R,Niero F,Ceccherini-Silberstein F,De Sanctis GM,Spanò A,Cappiello G,Perno CF |
Evidence
|
RtM204V clusters with mutations localized in the RT-B domain (rtV173L, rtL180M, and rtT184A/S) (bootstrap=0.94), while rtM204I clusters with mutations localized in the RT-A domain (rtS53N, rtT54Y, and rtL80I/V) (bootstrap=0.96) (without associations with HBsAg specific mutations).
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