HBV Mutation Detail Information

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Mutation Information

Mutation Site	M204I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	B
Country	China

Literature Information

PubMed PMID	21442057
Disease	Chronic hepatitis B
Published Year	2010
Journal	Hepatology international
Title	Predictors for early HBeAg loss during lamivudine therapy in HBeAg-positive chronic hepatitis B patients with acute exacerbation.
Author	Peng CY,Chen CB,Lai HC,Su WP,Chuang PH,Wu HD,Jeng LB
Evidence	Compared to compensated patients, decompensated patients achieved a higher rate of HBeAg loss (25.8 vs. 14.3%; P = 0.0805) at 3 months of therapy, a higher rate of serum HBV DNA negativity (53.2 vs. 29.8%; P = 0.0042), and a lower rate of rtM204V/I mutation (3.2 vs. 16.7%; P = 0.0139) after 12 months of lamivudine therapy.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation