HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	D
Relevant Drug	lamivudine (LAM)
Country	Italy

Literature Information

PubMed PMID	23026293
Disease	Chronic hepatitis B
Published Year	2012
Journal	Antiviral research
Title	Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy.
Author	Mirandola S,Sebastiani G,Rossi C,Velo E,Erne EM,Vario A,Tempesta D,Romualdi C,Campagnolo D,Alberti A
Evidence	In genotype D infected patients, seven mutations at five positions (rtL80I/V, rtV173L, rtL180M, rtT184I, rt204I/V) were significantly associated with LAM therapy (Fisher’s exact test; Benjamini–Hochberg adjusted p value < 0.05).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation