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Mutation Information
|
Mutation Site
|
M250I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
31189581
|
|
Disease
|
Chronic hepatitis B;
HBV associated liver disease;
HBV infection
|
|
Published Year
|
2019 |
|
Journal
|
Journal of clinical microbiology |
|
Title
|
Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing. |
|
Author
|
Fu Y,Zeng Y,Chen T,Chen H,Lin N,Lin J,Liu X,Huang E,Wu S,Wu S,Xu S,Wang L,Ou Q |
|
Evidence
|
The classical drug resistance mutations were not found by Sanger sequencing, while S202C/G/I (0.92% to ∼3.45%), M204I/V/S (0.90% to ∼8.32%), N236T (1.16% to ∼3.63%), and M250I/L/V (0.90% to ∼1.83%) were found at a low rate by NGS.
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HBV Mutation Detail Information