Mutation Information
Mutation Site
|
A181V |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Genotype/Subtype
|
C |
Relevant Drug
|
lamivudine (LAM) |
Country
|
Japan |
Literature Information
PubMed PMID
|
21503906
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2011 |
Journal
|
Journal of medical virology |
Title
|
Clinical course and predictive factors of virological response in long-term lamivudine plus adefovir dipivoxil combination therapy for lamivudine-resistant chronic hepatitis B patients. |
Author
|
Aizawa M,Tsubota A,Fujise K,Tatsuzawa K,Kono M,Hoshina S,Tajiri H |
Evidence
|
Breakthrough hepatitis occurred in three patients without complete viral response and with poor response to the preceding LAM monotherapy, and rtA181A/V substitution was detected in one of the three patients.
|
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