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Mutation Information
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Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV) |
|
Country
|
Finland |
Literature Information
|
PubMed PMID
|
22098177
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2012 |
|
Journal
|
Liver international : official journal of the International Association for the Study of the Liver |
|
Title
|
The influence of YMDD mutation patterns on clinical outcomes in patients with adefovir add-on lamivudine combination treatment. |
|
Author
|
Kim HJ,Park JH,Park DI,Cho YK,Sohn CI,Jeon WK,Kim BI |
|
Evidence
|
The proportion of patients in whom the log(10) HBV-DNA decreased <2 log(10) copies/ml, 6 months after the initiation of ADV add-on LAM combination treatment (non-responders), was significantly higher in patients with a rtM204V + rtM204I/V mutations than rtM204I mutation (7 [21.2%] vs. 2 [4.4%], P = 0.032).
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HBV Mutation Detail Information