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Mutation Information
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Mutation Site
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A181T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.N236T+rt.A181T+rt.A181V;rt.N236T+rt.A181T;rt.N236T+rt.A181T+rt.V173L+rt.S202I+rt.M204V+rt.L180M |
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Genotype/Subtype
|
B;C |
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Relevant Drug
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adefovir dipivoxil (ADV);entecavir (ETV);lamivudine (LAM);telbivudine (LDT);tenofovir (TDF) |
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Country
|
China |
Literature Information
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PubMed PMID
|
28017671
|
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Disease
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HBV infection
|
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Published Year
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2017 |
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Journal
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Journal of global antimicrobial resistance |
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Title
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Analysis of the prevalence of drug-resistant hepatitis B virus in patients with antiviral therapy failure in a Chinese tertiary referral liver centre (2010-2014). |
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Author
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Meng T,Shi X,Gong X,Deng H,Huang Y,Shan X,Shan Y,Huang A,Long Q |
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Evidence
|
The 3TC resistance rate increased from 39.8% in 2010 to 56.6% in 2013, before decreasing to 49.5% in 2014, evidence of a lagging effect of l-nucleoside consumption. M204I, N236T and L180M+M204V+V173L/S202G were the most common substitutions for l-nucleoside (3TC and LdT), ADV and ETV genotypic resistant phenotypes, respectively.
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HBV Mutation Detail Information