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Mutation Information
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Mutation Site
|
M250P |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
Literature Information
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PubMed PMID
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18435459
|
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Disease
|
HBV infection
|
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Published Year
|
2008 |
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Journal
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Hepatology (Baltimore, Md.) |
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Title
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Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance. |
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Author
|
Baldick CJ,Tenney DJ,Mazzucco CE,Eggers BJ,Rose RE,Pokornowski KA,Yu CF,Colonno RJ |
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Evidence
|
Residues both larger and smaller than the wild‐type methionine replicated reasonably, whereas residues that were basic (rtM250 K and R) or rtM250P, which can induce a structural turn, displayed very poor replication.
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HBV Mutation Detail Information