|
Mutation Information
|
Mutation Site
|
S202G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
entecavir (ETV) |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
17573951
|
|
Disease
|
HBV infection
|
|
Published Year
|
2008 |
|
Journal
|
Hepatology research : the official journal of the Japan Society of Hepatology |
|
Title
|
Changes in viral loads of lamivudine-resistant mutants during entecavir therapy. |
|
Author
|
Suzuki F,Suzuki Y,Akuta N,Yatsuji H,Sezaki H,Arase Y,Kawamura Y,Hosaka T,Kobayashi M,Ikeda K,Kobayashi M,Watahiki S,Kumada H |
|
Evidence
|
Analysis of the rt region sequences (amino acids 1–344) of HBV polymerase in one patient (no. 11) at 52 weeks showed a new substitution of rtS202G in addition to the lamivudine substitutions (rtL180M and rtM204V), which may indicate introduced ETV resistance.
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HBV Mutation Detail Information