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Mutation Information
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Mutation Site
|
S117C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
|
A |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
18171343
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2008 |
|
Journal
|
Journal of gastroenterology and hepatology |
|
Title
|
Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case. |
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Author
|
Bottecchia M,Ikuta N,Niel C,Araujo NM,O KM,Gomes SA |
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Evidence
|
The 2003 sequence displayed (i) a (C to G) substitution at nt 481 that affected both the S protein (L109V) and the rt domain of the polymerase (rtS117C), and (ii) a (G to C) change at nt 743, leading to the appearance of the lamivudine resistance YIDD motif.
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HBV Mutation Detail Information