HBV Mutation Detail Information

> F88Y Search Result

Mutation Information

Mutation Site	F88Y
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	19280622
Disease	Chronic hepatitis B
Published Year	2009
Journal	Hepatology (Baltimore, Md.)
Title	Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy.
Author	Tenney DJ,Rose RE,Baldick CJ,Pokornowski KA,Eggers BJ,Fang J,Wichroski MJ,Xu D,Yang J,Wilber RB,Colonno RJ
Evidence	One variant contained an F88Y substitution in a LVDr M204I/V+L180M background (Fig. 4, Year 4, second patient) and exhibited elevated ETV EC50 levels; however, this change did not reproducibly confer resistance in other cloned isolates from the same patient or when the change was engineered into laboratory background viruses.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation