|
Mutation Information
|
Mutation Site
|
L229F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L229F |
|
Relevant Drug
|
entecavir (ETV);telbivudine (LDT) |
|
Country
|
china |
Literature Information
|
PubMed PMID
|
33124952
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2020 |
|
Journal
|
Emerging microbes & infections |
|
Title
|
Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients. |
|
Author
|
Fu Y,Wu S,Hu Y,Chen T,Zeng Y,Liu C,Ou Q |
|
Evidence
|
The results revealed a relatively higher frequency of the mutation rtL229V (5/10, 50%) than rtL229M or rtL229F, and a correlation between rt229 substitutions and AA changes at rt204 or rt180 (6/10, 60%).
|
|
|
HBV Mutation Detail Information