|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
19817965
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2010 |
|
Journal
|
Journal of gastroenterology and hepatology |
|
Title
|
Occult hepatitis B virus infection and lamivudine-resistant mutations in isolates from renal patients undergoing hemodialysis. |
|
Author
|
Motta JS,Mello FC,Lago BV,Perez RM,Gomes SA,Figueiredo FF |
|
Evidence
|
Four of these six HBV isolates contained mutations associated with lamivudine resistance in the DNA polymerase (two with L180M/M204V and two with rt173V/180M/204V) and a specific substitution (Y100C) in the HBV small surface protein.
|
|
|
HBV Mutation Detail Information