|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M+rt.V173L |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV);tenofovir (TDF) |
Literature Information
|
PubMed PMID
|
15259898
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2004 |
|
Journal
|
Antiviral therapy |
|
Title
|
In vitro susceptibility of lamivudine-resistant hepatitis B virus to adefovir and tenofovir. |
|
Author
|
Lada O,Benhamou Y,Cahour A,Katlama C,Poynard T,Thibault V |
|
Evidence
|
In a clinical study of ADV (Gilead 460i study), seven of the 35 patients carried HBV strains with the triple lamivudine resistance-associated amino-acid changes rtV173L/L180M/M204V at baseline.
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HBV Mutation Detail Information