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Mutation Information
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Mutation Site
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L145M |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Country
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China |
Literature Information
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PubMed PMID
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26825915
|
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Disease
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HBV infection
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Published Year
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2016 |
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Journal
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Medicine |
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Title
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Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study. |
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Author
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Zhang XX,Li MR,Cao Y,Zhang RW,Zhang Y,Li F,Xi HL,Xu XY |
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Evidence
|
In addition to the common substitutions, unknown amino acid substitutions, such as rtL145 M/S, rtF151Y/L, rtR153Q, rtI224 V, rtN248H, rtS223A, rtS256C, need to be further verified. NAr substitutions are observed at frequencies of 0.10% to 6.7% before therapy.
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HBV Mutation Detail Information