Mutation Information
Mutation Site
|
L173V |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.M204V+rt.L180M+rt.L173V |
Relevant Drug
|
lamivudine (LAM) |
Literature Information
PubMed PMID
|
16549970
|
Disease
|
HBV-HIV coinfection
|
Published Year
|
2006 |
Journal
|
AIDS (London, England) |
Title
|
Characteristics of drug resistant HBV in an international collaborative study of HIV-HBV-infected individuals on extended lamivudine therapy. |
Author
|
Matthews GV,Bartholomeusz A,Locarnini S,Ayres A,Sasaduesz J,Seaberg E,Cooper DA,Lewin S,Dore GJ,Thio CL |
Evidence
|
The triple polymerase mutant (rtL173V, rtL180M, rtM204V), which behaves as a vaccine escape mutant in vitro, occurred in 17% of viraemic patients.
|
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