|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Turkish |
Literature Information
|
PubMed PMID
|
19152408
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2009 |
|
Journal
|
Journal of medical virology |
|
Title
|
Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir. |
|
Author
|
Zaaijer HL,Takkenberg RB,Weegink CJ,Rebers SP,Menting S,Reesink HW,Schinkel J,Molenkamp R |
|
Evidence
|
In both patients serial monotherapy caused the replacement in all HBV clones of wild-type virus by classical lamivudine resistant mutants (L180M and M204V/I), which were replaced subsequently by adefovir resistant mutants (A181V and N236T).
|
|
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HBV Mutation Detail Information