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Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
17215289
|
|
Published Year
|
2007 |
|
Journal
|
Journal of virology |
|
Title
|
In vitro study of the effects of precore and lamivudine-resistant mutations on hepatitis B virus replication. |
|
Author
|
Heipertz RA Jr,Miller TG,Kelley CM,Delaney WE 4th,Locarnini SA,Isom HC |
|
Evidence
|
We concluded that the rtM204I mutation generates a polymerase that is not only resistant to lamivudine but also replicates nucleic acids to lower levels in vitro.
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HBV Mutation Detail Information