HBV Mutation Detail Information

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Mutation Information

Mutation Site	N53T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	p.M309K+rt.L229V+rt.K212Q+rt.A200V+rt.A181I+rt.S135T+rt.S85F+rt.S78T+rt.N53T;p.M309K+rt.L229F+rt.K212Q+rt.A200V+rt.A181I+rt.S135T+rt.S85F+rt.S78T+rt.N53T
Country	Italy

Literature Information

PubMed PMID	23796863
Disease	HBV infection
Published Year	2013
Journal	The Journal of infection
Title	Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.
Author	Cento V,Van Hemert F,Neumann-Fraune M,Mirabelli C,Di Maio VC,Salpini R,Bertoli A,Micheli V,Gubertini G,Romano S,Visca M,De Sanctis GM,Berkhout B,Marino N,Mazzotta F,Cappiello G,Spanò A,Sarrecchia C,Ceccherini-Silberstein F,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V
Evidence	RESULTS: Ten novel RT-mutations (rtN53T-rtS78T-rtS85F-rtS135T-rtA181I-rtA200V-rtK212Q-rtL229V/F-rtM309K) correlated with specific NUC-treatments and classical drug-resistance mutations on divergent evolutionary pathways.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation