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Mutation Information
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Mutation Site
|
M204I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Viral Reference
|
AB179747;
AY090460;
AF160501;
X75663;
X75664;
X75657;
X02496;
X65257;
V00867;
AB033556;
D00330;
D00329;
X70185;
X02763;
M57663 |
|
Country
|
China |
Literature Information
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PubMed PMID
|
22170539
|
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Disease
|
Chronic hepatitis B
|
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Published Year
|
2012 |
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Journal
|
Journal of medical virology |
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Title
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Discrepancy of potential antiviral resistance mutation profiles within the HBV reverse transcriptase between nucleos(t)ide analogue-untreated and -treated patients with chronic hepatitis B in a hospital in China. |
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Author
|
Li XG,Liu BM,Xu J,Liu XE,Ding H,Li T |
|
Evidence
|
Substitutions at seven non-classical mutation sites were of interest due to either detection only in patients with virologic breakthrough (rtL82 and rtV214), or potential ties with HBV genotypes (rtV191 and rtL229), or coexistence with rtM204I/V (rtL229), or increased mutation trends after NA-treatment (rtT128, rtV207, and rtN/H238).
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HBV Mutation Detail Information