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Mutation Information
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Mutation Site
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A181T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Combined Mutation
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rt.A181T+rt.N236T+s.C69*+rt.S78T;rt.A181T+rt.N236T+rt.A181V+s.C69*+rt.S78T;rt.A181T+rt.A181V+s.C69*+rt.S78T;rt.N236T+rt.M204V+rt.A181T+rt.L180M+s.C69*+rt.S78T |
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Country
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China |
Literature Information
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PubMed PMID
|
31398372
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Disease
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Chronic hepatitis B
|
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Published Year
|
2019 |
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Journal
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Antiviral research |
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Title
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Investigation of hepatitis B virus (HBV) rtS78T/sC69* mutation in a large cohort of chronic HBV-infected patients with nucleoside/nucleotide analogue treatment. |
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Author
|
Luo D,Liu Y,Chen R,Niu M,Liu L,Li X,Li Q,Huang B,Wang J,Xu D,Lin S |
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Evidence
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The rtS78T/sC69*-containing mutants, including rtS78T/sC69*, rtS78T/sC69* + A181T, rtS78T/sC69* + N236T, and/or rtS78T/sC69* + A181T + N236T, were detected in various proportions during ETV therapy in samples B1, B2, and B3, and after the suspension of ETV therapy in sample B4 (Fig. 2B).
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HBV Mutation Detail Information