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Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.V173L+rt.L180M+rt.M204I+rt.M204V;rt.L80I+rt.V173L+rt.M204I |
|
Viral Reference
|
X70185
|
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV);adefovir dipivoxil (ADV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
17913933
|
|
Disease
|
Chronic hepatitis B
|
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Published Year
|
2007 |
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Journal
|
Journal of clinical microbiology |
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Title
|
Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay. |
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Author
|
Libbrecht E,Doutreloigne J,Van De Velde H,Yuen MF,Lai CL,Shapiro F,Sablon E |
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Evidence
|
In all 20 patients, the mutation occurred in the YMDD motif at reverse transcriptase position 204 (rt204; M204V/I) either with or without the compensatory mutation at position rt180 (L180M).
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HBV Mutation Detail Information