|
Mutation Information
|
Mutation Site
|
I91L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
D |
|
Viral Reference
|
X72702;
AY796031;
AY741796;
AY661792;
AY796030;
AY721605 |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Turkey |
Literature Information
|
PubMed PMID
|
24630522
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Diagnostic microbiology and infectious disease |
|
Title
|
Analysis of potential antiviral resistance mutation profiles within the HBV reverse transcriptase in untreated chronic hepatitis B patients using an ultra-deep pyrosequencing method. |
|
Author
|
Ciftci S,Keskin F,Cakiris A,Akyuz F,Pinarbasi B,Abaci N,Dincer E,Badur S,Kaymakoglu S,Ustek D |
|
Evidence
|
The patient A11 receiving no LAM therapy had the rtL91I and rtC256S putative antiviral resistance mutations (ratio; 5.3% and 70.2%) associated with LAM treatment. The rtQ215P and rtF221Y putative antiviral resistance mutations were detected in subject B3 (ratio; 30.3% and 100%) that are associated with ADV resistance. This patient had not received ADV therapy.
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|
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HBV Mutation Detail Information