|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L180M;rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Malawi |
Literature Information
|
PubMed PMID
|
22930502
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2012 |
|
Journal
|
Journal of medical virology |
|
Title
|
Emergence of lamivudine resistance hepatitis B virus mutations in pregnant women infected with HBV and HIV receiving antiretroviral prophylaxis for the prevention of mother-to-infant transmission in Malawi. |
|
Author
|
Galluzzo C,Liotta G,Andreotti M,Luhanga R,Jere H,Mancinelli S,Maulidi M,Sagno JB,Pirillo M,Erba F,Amici R,Ceffa S,Marazzi MC,Vella S,Palombi L,Giuliano M |
|
Evidence
|
Resistance mutations (M204I in five cases and L180M + M204I/V in one case) were present in 6 (28.6%) patients.
|
|
|
HBV Mutation Detail Information