HBV Mutation Detail Information

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Mutation Information

Mutation Site	A181T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	lamivudine (LAM);adefovir (ADV);tenofovir (TDF)
Country	Italy

Literature Information

PubMed PMID	23796863
Disease	HBV infection
Published Year	2013
Journal	The Journal of infection
Title	Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.
Author	Cento V,Van Hemert F,Neumann-Fraune M,Mirabelli C,Di Maio VC,Salpini R,Bertoli A,Micheli V,Gubertini G,Romano S,Visca M,De Sanctis GM,Berkhout B,Marino N,Mazzotta F,Cappiello G,Spanò A,Sarrecchia C,Ceccherini-Silberstein F,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V
Evidence	Indeed, rtS78T (prevalence: 1.1% in drug-naive and 12.2% in adefovir-failing patients) decreased the RT-affinity for adefovir more than the classical adefovir-resistance mutations rtA181 T/V (WT:-9.63 kcal/mol, rtA181T:-9.30 kcal/mol, rtA181V:-7.96 kcal/mol, rtS78T:-7.37 kcal/mol).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation