HBV Mutation Detail Information

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Mutation Information

Mutation Site	A194T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	A
Viral Reference	AF305422
Relevant Drug	lamivudine (LAM);tenofovir (TDF)

Literature Information

PubMed PMID	16801428
Published Year	2006
Journal	Antimicrobial agents and chemotherapy
Title	Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus.
Author	Delaney WE 4th,Ray AS,Yang H,Qi X,Xiong S,Zhu Y,Miller MD
Evidence	Here we show that the major adefovir resistance mutation, rtN236T, confers three- to fourfold-reduced susceptibility to tenofovir in cell culture; the clinical significance of this susceptibility shift has not yet been determined. The rtA194T HBV polymerase mutation recently identified in tenofovir DF-treated HIV/HBV-coinfected patients did not confer in vitro resistance to tenofovir as a single mutation or in a lamivudine-resistant viral background.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation