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Mutation Information
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Mutation Site
|
M552V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
11596084
|
|
Disease
|
HBV infection
|
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Published Year
|
2001 |
|
Journal
|
Journal of medical virology |
|
Title
|
Residual hepatitis B virus particles in liver transplant recipients receiving lamivudine: PCR quantitation of HBV DNA and ELISA of preS1 antigen. |
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Author
|
Petit MA,Buffello-Le Guillou D,Roche B,Dussaix E,Duclos-Vallée JC,Féray C,Samuel D |
|
Evidence
|
Pol gene sequencing before andafter the breakthrough showed the selection of viralmutants in the catalytic site of the pol gene: M552V(YVDD) in patient 6, and M552I (YIDD) in patient 7 and another common mutation (L528M) in the Bdomain of the pol gene.
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HBV Mutation Detail Information