|
Mutation Information
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Mutation Site
|
N134D |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B2 |
|
Viral Reference
|
AB073830;
AB073823;
AF121251;
AF121243 |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
27006281
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2016 |
|
Journal
|
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases |
|
Title
|
Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2. |
|
Author
|
Su M,Xiang K,Li Y,Li Y,Deng J,Xu X,Yan L,Zhuang H,Li T |
|
Evidence
|
The most frequently detected substitutions were rtN134D/S (44/143, 30.8%) and sT126A/S (22/143, 15.4%), which were located in the RT A-B interdomain region and the corresponding antigenicity determinant region of S protein, respectively.
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HBV Mutation Detail Information