HBV Mutation Detail Information

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Mutation Information
Mutation Site L180M
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.M204V+rt.L180M
Relevant Drug lamivudine (LAM);adefovir (ADV)
Country Japan
Literature Information
PubMed PMID 20367795
Disease HBV infection
Published Year 2011
Journal Journal of viral hepatitis
Title Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern.
Author Inoue J,Ueno Y,Wakui Y,Niitsuma H,Fukushima K,Yamagiwa Y,Shiina M,Kondo Y,Kakazu E,Tamai K,Obara N,Iwasaki T,Shimosegawa T
Evidence An rtA200V mutation was present in the majority of HBV clones, in addition to the 3TC-resistant mutations of rtL180M+M204V.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation