|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Iran |
Literature Information
|
PubMed PMID
|
19586679
|
|
Disease
|
HBV infection
|
|
Published Year
|
2009 |
|
Journal
|
Journal of hepatology |
|
Title
|
Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome. |
|
Author
|
Amini-Bavil-Olyaee S,Herbers U,Mohebbi SR,Sabahi F,Zali MR,Luedde T,Trautwein C,Tacke F |
|
Evidence
|
Replication-competent HBV constructs containing the naturally occurring rtQ215H, rtQ215P and rtQ215S mutations were generated, and compared to wild-type, LAM- (rtM204I, rtL180M/rtM204V) and ADV-resistant (rtN236T) clones.
|
|
|
HBV Mutation Detail Information