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Mutation Information
|
Mutation Site
|
N236T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
adefovir (ADV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
20222172
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2010 |
|
Journal
|
World journal of gastroenterology |
|
Title
|
Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application. |
|
Author
|
Zhao WF,Shao YL,Chen LY,Wu JH,Zhu YL,Gan JH,Xiong H |
|
Evidence
|
METHODS: Based on the characteristics of rtA181V/T and rtN236T mutations, a new approach based on real-time fluorescent quantitative polymerase chain reaction (RT-PCR) was established for the detection of ADV-resistant HBV quasispecies, total HBV DNA, rtA181 and rtN236 mutations in blood samples from 32Chronic hepatitis B(CHB) patients with unsatisfactory curative effect on ADV and compared with routine HBV DNA sequencing.
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HBV Mutation Detail Information