|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.S202G+rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Literature Information
|
PubMed PMID
|
17935165
|
|
Disease
|
HBV infection
|
|
Published Year
|
2007 |
|
Journal
|
Journal of medical virology |
|
Title
|
Successful treatment of an entecavir-resistant hepatitis B virus variant. |
|
Author
|
Yatsuji H,Hiraga N,Mori N,Hatakeyama T,Tsuge M,Imamura M,Takahashi S,Fujimoto Y,Ochi H,Abe H,Maekawa T,Suzuki F,Kumada H,Chayama K |
|
Evidence
|
Direct sequence analysis of the ETV-resistant strain showed appearance of amino acid substitution rtS202G in the reverse transcriptase (RT) domain, together with rtL180M + M204V substitution that had developed at the emergence of LAM-resistant mutant.
|
|
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HBV Mutation Detail Information