HBV Mutation Detail Information

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Mutation Information

Mutation Site	M204I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	D
Relevant Drug	lamivudine (LAM);adefovir (ADV)

Literature Information

PubMed PMID	12500185
Published Year	2003
Journal	Hepatology (Baltimore, Md.)
Title	Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro.
Author	Chen RY,Edwards R,Shaw T,Colledge D,Delaney WE 4th,Isom H,Bowden S,Desmond P,Locarnini SA
Evidence	HBV baculoviruses encoding the G1896A PC stop codon mutation were generated in wild-type (WT) and lamivudine-resistant (rtM204I and rtL180M + rtM204V) backgrounds, resulting in a panel of 6 related recombinant baculoviruses.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation