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Mutation Information
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Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
15328117
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2004 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine. |
|
Author
|
Tenney DJ,Levine SM,Rose RE,Walsh AW,Weinheimer SP,Discotto L,Plym M,Pokornowski K,Yu CF,Angus P,Ayres A,Bartholomeusz A,Sievert W,Thompson G,Warner N,Locarnini S,Colonno RJ |
|
Evidence
|
For liver transplant patient B (AI463015-B), previous famciclovir, ganciclovir, foscarnet, and 3TC therapies had failed, and RT changes rtS78S/T, rtV173L, rtL180M, rtT184S, and rtM204V were present at study entry.
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HBV Mutation Detail Information