HBV Mutation Detail Information

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Mutation Information

Mutation Site	M204S
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	B;C;D

Literature Information

PubMed PMID	17438047
Published Year	2007
Journal	Antimicrobial agents and chemotherapy
Title	The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro.
Author	Warner N,Locarnini S,Kuiper M,Bartholomeusz A,Ayres A,Yuen L,Shaw T
Evidence	Mutations that result in the replacement of the methionine at position 204 of the deoxynucleoside triphosphate-binding site of the hepatitis B virus (HBV) reverse transcriptase (rt) by isoleucine, valine, or (rarely) serine (rtM204I/V/S) confer high-level resistance to LMV but reduce replication efficiency.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation