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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.L180M+rt.M204V+rt.A181V;rt.L180M+rt.M204V+rt.A181T |
|
Relevant Drug
|
adefovir (ADV);lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
26164128
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2016 |
|
Journal
|
Clinical and experimental medicine |
|
Title
|
Comparison of entecavir monotherapy and de novo lamivudine and adefovir combination therapy in HBeAg-positive chronic hepatitis B with high viral load: 48-week result. |
|
Author
|
Cai S,Yu T,Jiang Y,Zhang Y,Lv F,Peng J |
|
Evidence
|
Two cases of genotypic resistance were found (rtM204 V + rtL180 M and rtA181T/V) in the LAM + ADV group, with a resistance rate of 4.3 %; there was no genotypic resistance in the entecavir group (P = 0.13).
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HBV Mutation Detail Information