HBV Mutation Detail Information

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Mutation Information
Mutation Site M204V
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.M204V+rt.S202G+rt.L180M;rt.M204V+rt.L180M+rt.V173L;rt.M204V+rt.S202G+rt.A181G+rt.L180M;rt.M204V+rt.S202G+rt.L180M+rt.P177S+rt.V173L;rt.M204V+rt.S202G+rt.I169L+rt.L180M
Relevant Drug lamivudine (LAM);entecavir (ETV)
Literature Information
PubMed PMID 17239478
Disease Chronic hepatitis B; Liver cirrhosis
Published Year 2007
Journal Journal of hepatology
Title Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient.
Author Villet S,Ollivet A,Pichoud C,Barraud L,Villeneuve JP,Trépo C,Zoulim F
Evidence Although the rtL180M+S202G+M204V variant, that prevailed at the end of entecavir therapy, did not show the highest viral genome replication capacity, it conferred one of the strongest resistance levels to entecavir.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation