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Mutation Information
|
Mutation Site
|
A181C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.A181C+rt.L180M |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
30796932
|
|
Disease
|
HBV infection
|
|
Published Year
|
2019 |
|
Journal
|
Antiviral research |
|
Title
|
Prevalence of the entecavir-resistance-inducing mutation rtA186T in a large cohort of Chinese hepatitis B virus patients. |
|
Author
|
Liu L,Liu Y,Chen R,Li X,Luo D,Zhao Y,Li Q,Huang B,Wang FS,Liu X,Xu D |
|
Evidence
|
At the time of virological breakthrough (VBT) in response to ETV (sample A1), rtL180M+A186T+M204V, rtL180M+M204V, rtL180M+A181C+M204V, and rtL180M+T184S+A186T+M204V mutants and the wild-type strain were detected in 58%, 19%, 13%, 5%, and 5% of the tested viral clones, respectively.
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HBV Mutation Detail Information