HBV Mutation Detail Information

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Mutation Information

Mutation Site	I169T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204V+rt.L180M+rt.V173L+rt.I169T
Genotype/Subtype	D
Relevant Drug	lamivudine (LAM);entecavir (ETV)

Literature Information

PubMed PMID	18571815
Disease	Chronic hepatitis B
Published Year	2008
Journal	Hepatology (Baltimore, Md.)
Title	Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance.
Author	Preiss S,Littlejohn M,Angus P,Thompson A,Desmond P,Lewin SR,Sasadeusz J,Matthews G,Dore GJ,Shaw T,Sozzi V,Yuen L,Lau G,Ayres A,Thio C,Avihingsanon A,Ruxrungtham K,Locarnini S,Revill PA
Evidence	The mutants examined in the genotype D clone included the famciclovir-resistant mutant rtL180M; the lamivudine-resistant mutants rtM204I, rtL180M+rtM204V, and rtV173L+rtL180M+rtM204V; the lamivudine and entecavir-resistant mutants rtI169T+rtV173L+rtL180M+rtM204V, rtI169T+rtV173L+rtL180M+rtM204V+rtM250V, and rtL180M+rtT184G+rtS202I+rtM204V; and the adefovir-resistant mutants rtA181T, rtN236T, and rtA181T+rtN236T.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation