|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
s.W196L+rt.M204I;rt.S223A+s.W196L+rt.M204I;s.W196L+rt.M204I |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
16830379
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2006 |
|
Journal
|
World journal of gastroenterology |
|
Title
|
Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs. |
|
Author
|
Lu HY,Zeng Z,Xu XY,Zhang NL,Yu M,Gong WB |
|
Evidence
|
Lamivudine (LMV)-selected mutations were found in three patients who developed anti-HBs, which occurred in amino acid positions (196, 198, 199) of the surface protein and in YMDD motif (M204I/V) of the polymerase protein simultaneously.
|
|
|
HBV Mutation Detail Information