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Mutation Information
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Mutation Site
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H238D |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Country
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China |
Literature Information
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PubMed PMID
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31189581
|
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Disease
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Chronic hepatitis B;
HBV associated liver disease;
HBV infection
|
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Published Year
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2019 |
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Journal
|
Journal of clinical microbiology |
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Title
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Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing. |
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Author
|
Fu Y,Zeng Y,Chen T,Chen H,Lin N,Lin J,Liu X,Huang E,Wu S,Wu S,Xu S,Wang L,Ou Q |
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Evidence
|
Also, rtS213T, rtV214A, rtL229G/V/W/F, N/H238D/T, and S/C256G were detected in 13 patients by both Sanger sequencing and NGS, including 3 patients with rtS213T (98.44%, 46.88%, and 80.97% by NGS), 2 with rtV214A (49.18% and 99.24%), 1 with rtL229V (50.84%), 1 with rtN238T (98.85%), 5 with S/C256G (97.28%, 97.93%, 92.26%, 97.79%, and 98.31%), and 1 with rtL229V plus rtS/C256G (82.36% for rtL229V and 74.81% for rtS/C256G).
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HBV Mutation Detail Information