|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.A181S+rt.V84M |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
21056552
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2011 |
|
Journal
|
Clinica chimica acta; international journal of clinical chemistry |
|
Title
|
Variable influence of mutational patterns in reverse-transcriptase domain on replication capacity of hepatitis B virus isolates from antiviral-experienced patients. |
|
Author
|
Ji D,Liu Y,Si LL,Li L,Chen GF,Xin SJ,Zhao JM,Xu D |
|
Evidence
|
Compared to wild-type counterpart, mutant rtL217P produced 1.98-fold higher replicative intermediate level, and mutant rtM204I+rtL217P increased the replicative intermediate level to 1.20 fold.
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|
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HBV Mutation Detail Information