|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Genotype/Subtype
|
A |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
19889778
|
|
Published Year
|
2010 |
|
Journal
|
Journal of virology |
|
Title
|
Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains. |
|
Author
|
Amini-Bavil-Olyaee S,Vucur M,Luedde T,Trautwein C,Tacke F |
|
Evidence
|
Replication-competent HBV strains with sG145R or sP120T and LAM resistance (rtM204I or rtL180M/rtM204V) were generated on an HBeAg-positive and an HBeAg-negative background with precore (PC) and basal core promoter (BCP) mutants.
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HBV Mutation Detail Information