HBV Mutation Detail Information

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Mutation Information

Mutation Site	I169T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.A194T+rt.I169T+rt.A181T+rt.M204V;rt.A194T+rt.I169T+rt.A181V+rt.M204V

Literature Information

PubMed PMID	21831732
Disease	HBV infection
Published Year	2011
Journal	Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Title	Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development.
Author	Svicher V,Cento V,Salpini R,Mercurio F,Fraune M,Beggel B,Han Y,Gori C,Wittkop L,Bertoli A,Micheli V,Gubertini G,Longo R,Romano S,Visca M,Gallinaro V,Marino N,Mazzotta F,De Sanctis GM,Fleury H,Trimoulet P,Angelico M,Cappiello G,Zhang XX,Verheyen J,Ceccherini-Silberstein F,Perno CF
Evidence	Highest genetic barrier is found for secondary/compensatory mutations (e.g. rtL80I/V-rtL180M-rtV173L), whilst most primary mutations (including rtM204V-rtA181T/V-rtI169T-rtA194T) are associated with low genetic barrier.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation