Mutation Information
Mutation Site
|
M204I |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Relevant Drug
|
lamivudine (LAM) |
Literature Information
PubMed PMID
|
16856618
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2006 |
Journal
|
Antiviral therapy |
Title
|
The clinical impact of early detection of the YMDD mutant on the outcomes of long-term lamivudine therapy in patients with chronic hepatitis B. |
Author
|
Paik YH,Han KH,Hong SP,Lee HW,Lee KS,Kim SO,Shin JE,Ahn SH,Chon CY,Moon YM |
Evidence
|
Cumulative viral breakthrough rates at 3 years was 75.0% and 14.3% in patients who had the rtM204I mutant and wild-type virus at 3 months, respectively (P=0.002).
|
|
|