|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
16928212
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2006 |
|
Journal
|
Journal of gastroenterology and hepatology |
|
Title
|
Association of core promoter mutations with viral breakthrough in chronic hepatitis B patients on long-term lamivudine therapy. |
|
Author
|
Kazim SN,Chauhan R,Das BC,Sarin SK |
|
Evidence
|
Virologic breakthrough (VBTH) during long-term lamivudine therapy is believed to be due to the emergence of rtYM204I/VDD mutants.
|
|
|
HBV Mutation Detail Information