|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
AB033550
|
|
Relevant Drug
|
tenofovir (TDF);entecavir (ETV) |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
25061278
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Drug design, development and therapy |
|
Title
|
Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir. |
|
Author
|
Suzuki F,Sezaki H,Akuta N,Suzuki Y,Kawamura Y,Hosaka T,Kobayashi M,Saitoh S,Arase Y,Ikeda K,Kobayashi M,Watahiki S,Mineta R,Suzuki Y,Kumada H |
|
Evidence
|
In October 2007 (after switching from LAM to ETV), an amino acid substitution of the rt gene, rtM204I (LAM resistance substitution), was detected.
|
|
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HBV Mutation Detail Information